| Kolo | Datum/Vreme | Utakmica | Rezultat |
|---|---|---|---|
| 1 | 03.10.2021 16:00 | Aleksinac - Mladost | 18:21 |
| 2 | 10.10.2021 13:00 | Mladost - Vranje | 24:21 |
| 3 | 15.10.2021 20:30 | Osice - Mladost | 45:32 |
| 5 | 30.10.2021 15:00 | Mladost - Radan | 31:19 |
| 6 | 06.11.2021 19:30 | Remesiana - Mladost | 35:27 |
| 7 | 14.11.2021 16:00 | Mladost - Vlasotince | 22:26 |
| 8 | 20.11.2021 13:00 | RSU Feniks - Mladost | 32:25 |
| 9 | 26.11.2021 18:00 | Mladost - Žitorađa | 33:29 |
| 10 | 06.03.2022 18:00 | Mladost - Aleksinac | 30:21 |
| 11 | 13.03.2022 13:00 | Vranje - Mladost | 33:28 |
| 12 | 20.03.2022 18:00 | Mladost - Osice | 27:43 |
| 14 | 03.04.2022 13:00 | Radan - Mladost | 26:26 |
| 15 | 09.04.2022 15:30 | Mladost - Remesiana | 33:32 |
| 16 | 17.04.2022 18:00 | Vlasotince - Mladost | 45:28 |
| 17 | 02.05.2022 18:00 | Mladost - RSU Feniks | 28:29 |
| 18 | 08.05.2022 19:00 | Žitorađa - Mladost | 31:27 |
| Poz | Tim | Utak | Pob | Ner | Por | DG | PG | GR | Forma | Bod | |
| 1 | Vlasotince | 16 | 14 | 0 | 2 | 470 | 338 | +132 | 1 2 1 1 1 | 28 | |
| 2 | Osice | 16 | 12 | 2 | 2 | 557 | 424 | +133 | 2 1 1 1 1 | 26 | |
| 3 | Remesiana | 16 | 13 | 0 | 3 | 437 | 346 | +91 | 1 1 2 1 2 | 26 | |
| 4 | Vranje | 16 | 7 | 4 | 5 | 373 | 341 | +32 | 2 2 1 X 1 | 18 | |
| 5 | RSU Feniks | 16 | 7 | 1 | 8 | 400 | 399 | +1 | 1 2 2 1 1 | 15 | |
| 6 | Mladost | 16 | 6 | 1 | 9 | 442 | 485 | -43 | X 1 2 2 2 | 13 | |
| 7 | Aleksinac | 16 | 3 | 1 | 12 | 359 | 448 | -89 | 2 2 1 2 2 | 7 | |
| 8 | Radan | 16 | 2 | 2 | 12 | 309 | 461 | -152 | 2 X 2 2 2 | 6 | |
| 9 | Žitorađa | 16 | 2 | 1 | 13 | 365 | 470 | -105 | 2 2 X 2 1 | 5 | |
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