| Kolo | Datum/Vreme | Utakmica | Rezultat |
|---|---|---|---|
| 1 | 13.10.2021 20:30 | Vranje - Osice | 26:26 |
| 3 | 15.10.2021 20:30 | Osice - Mladost | 45:32 |
| 4 | 24.10.2021 13:00 | Radan - Osice | 20:28 |
| 5 | 29.10.2021 20:30 | Osice - Remesiana | 32:24 |
| 6 | 06.11.2021 19:00 | Vlasotince - Osice | 34:30 |
| 7 | 12.11.2021 20:00 | Osice - RSU Feniks | 35:24 |
| 8 | 20.11.2021 17:00 | Žitorađa - Osice | 24:36 |
| 9 | 26.11.2021 20:00 | Osice - Aleksinac | 46:21 |
| 10 | 06.03.2022 18:00 | Osice - Vranje | 26:26 |
| 12 | 20.03.2022 18:00 | Mladost - Osice | 27:43 |
| 13 | 26.03.2022 20:30 | Osice - Radan | 36:20 |
| 14 | 02.04.2022 15:30 | Remesiana - Osice | 35:29 |
| 15 | 14.04.2022 20:45 | Osice - Vlasotince | 32:29 |
| 16 | 16.04.2022 20:45 | RSU Feniks - Osice | 31:33 |
| 17 | 28.04.2022 19:00 | Osice - Žitorađa | 43:25 |
| 18 | 09.05.2022 19:00 | Aleksinac - Osice | 26:37 |
| Poz | Tim | Utak | Pob | Ner | Por | DG | PG | GR | Forma | Bod | |
| 1 | Vlasotince | 16 | 14 | 0 | 2 | 470 | 338 | +132 | 1 2 1 1 1 | 28 | |
| 2 | Osice | 16 | 12 | 2 | 2 | 557 | 424 | +133 | 2 1 1 1 1 | 26 | |
| 3 | Remesiana | 16 | 13 | 0 | 3 | 437 | 346 | +91 | 1 1 2 1 2 | 26 | |
| 4 | Vranje | 16 | 7 | 4 | 5 | 373 | 341 | +32 | 2 2 1 X 1 | 18 | |
| 5 | RSU Feniks | 16 | 7 | 1 | 8 | 400 | 399 | +1 | 1 2 2 1 1 | 15 | |
| 6 | Mladost | 16 | 6 | 1 | 9 | 442 | 485 | -43 | X 1 2 2 2 | 13 | |
| 7 | Aleksinac | 16 | 3 | 1 | 12 | 359 | 448 | -89 | 2 2 1 2 2 | 7 | |
| 8 | Radan | 16 | 2 | 2 | 12 | 309 | 461 | -152 | 2 X 2 2 2 | 6 | |
| 9 | Žitorađa | 16 | 2 | 1 | 13 | 365 | 470 | -105 | 2 2 X 2 1 | 5 | |
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